Diana Stafforini Ph.D.

Reviewer Experience

Critical assessment of grant proposals and projects for funding agencies, including:

  • 2013, 2015 Department of Defense, member of peer review panel, Congressionally Directed Medical Research Program on Prostate Cancer, Cell Biology
  • 2008, 2013 National Cancer Institute, site visitor, Cancer Center Support Grant
  • 2009 University of British Columbia, dissertation external reviewer
  • 2005-2009 National Institutes of Health, member of Study Section Erythrocyte and Leukocyte Biology
  • 2007 Singapore Agency for Science, Technology & Research, grant reviewer
  • 2006 American Heart Association Western 4B, grant reviewer
  • 2005 Ohio Cancer Research Associates, grant reviewer
  • 2004 National Institutes of Health, ad-hoc reviewer, Asthma Exacerbations: Biology and Disease Progression
  • 2004 Austrian Science Fund (FWF), grant reviewer

Academic Experience

Positions held at the University of Utah, Salt Lake City, UT, USA

  • 2016-present, Associate Director, HCI CEO Office, Huntsman Cancer Institute
  • 2014-2020, Research Professor, Huntsman Cancer Institute and Department of Internal Medicine
  • 2000-2014, Research Associate Professor, Huntsman Cancer Institute and Department of Internal Medicine
  • 1992-2000, Research Assistant Professor, Program in Human Molecular Biology and Genetics and Department of Internal Medicine
  • 1989-1992, Research Instructor, Nora Eccles Harrison Cardiovascular Research and Training Institute and Department of Internal Medicine

Education

Research Associate, 1986-1989. Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah

Identification and characterization of biologically active oxidized phospholipids as mediators of inflammation

Doctoral Student (Ph.D.). 1981-1986 Department of Biochemistry, University of Utah

Purification and characterization of human plasma Platelet-activating Factor Acetylhydrolase Advisor: Stephen M. Prescott, MD

Undergraduate Student (B. Sc.). 1973-1978 University of Buenos Aires, Argentina. Major: Chemistry, Minor: Biological Chemistry.

Other Selected Professional Experience

Administrative

  • 2016-2019 Member, School of Medicine Faculty Appointment Review and Advancement Committee
  • 2003-2014 Member, School of Medicine Admissions Selection Committee

Educational

  • 2009-2014  Graduate-level lecturer, Lipid Signaling in Inflammation
  • 1998-2005  Director, Huntsman Cancer Institute Internship Program

Editorial

  • 2015   Editor, The Enzymes, Academic Press/Elsevier

Advisory

  • 1992-2006  Consultant, ICOS Corporation, Bothell, WA

Select Publications

Matsumiya T, Xing F, Ebina M, Hayakari R, Imaizumi T, Yoshida H, Kikuchi H, Topham MK, Satoh K, Stafforini DM (2013). Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-epsilon expression. J Immunol 191, 1907.


Xu C, Reichert EC, Nakano T, Lohse M, Gardner AA, Revelo MP, Topham MK, Stafforini DM (2013). Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice. Cancer Res 73, 2806.


Matsumiya T, Imaizumi T, Yoshida H, Satoh K, Topham MK, Stafforini DM (2009). The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha. J Immunol 182, 2717.


Gardner AA, Reichert EC, Topham MK, Stafforini DM (2008). Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein. J Biol Chem 283, 17099.


Eisinger AL, Nadauld LD, Shelton DN, Prescott SM, Stafforini DM, Jones DA (2007). Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli. J Biol Chem, 282, 29394.


MacRitchie AN, Gardner AA, Prescott SM, Stafforini DM (2007). Molecular basis for susceptibility of plasma platelet-activating factor acetylhydrolase to oxidative inactivation. FASEB J 21, 1164.


Stafforini DM, Sheller JR, Blackwell TS, Sapirstein A, Yull FE, McIntyre TM, Bonventre JV, Prescott SM, Roberts LJ 2nd (2006). Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J Biol Chem 281, 4616.


Cipollone F, Mezzetti A, Fazia ML, Cuccurullo C, Iezzi A, Ucchino S, Spigonardo F, Bucci M, Cuccurullo F, Prescott SM, Stafforini DM (2005). Association between 5-lipoxygenase expression and plaque instability in humans. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 1665.


Wu X, Zimmerman GA, Prescott SM, Stafforini DM (2004). The p38 MAPK pathway mediates transcriptional activation of the plasma platelet-activating factor acetylhydrolase gene in macrophages stimulated with lipopolysaccharide. J Biol Chem 279, 36158.


Stafforini DM, Numao T, Tsodikov A, Vaitkus D, Fukuda T, Watanabe N, Fueki N, McIntyre TM, Zimmerman GA, Makino S, Prescott SM (1999). Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma. J Clin Invest 103, 989.


Stafforini DM, Tjoelker LW, McCormick SP, Vaitkus D, McIntyre TM, Gray PW, Young SG, Prescott SM (1999). Molecular basis of the interaction between plasma platelet-activating factor acetylhydrolase and low density lipoprotein. J Biol Chem 274, 7018.


Stafforini DM, Satoh K, Atkinson DL, Tjoelker LW, Eberhardt C, Yoshida H, Imaizumi T, Takamatsu S, Zimmerman GA, McIntyre TM, Gray PW, Prescott SM (1996). Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase. J Clin Invest 97, 2784.


Tjoelker LW, Wilder C, Eberhardt C, Stafforini DM, Dietsch G, Schimpf B, Hooper S, Le Trong H, Cousens LS, Zimmerman GA, Yamada Y, McIntyre TM, Prescott SM, Gray PW (1995). Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 374, 549.


Stafforini DM, Rollins EN, Prescott SM, McIntyre TM (1993). The platelet-activating factor acetylhydrolase from human erythrocytes. Purification and properties. J Biol Chem 268, 3857.


Stafforini DM, Elstad MR, McIntyre TM, Zimmerman GA, Prescott SM (1990). Human macrophages secret platelet-activating factor acetylhydrolase. J Biol Chem 265, 9682.


Stafforini DM, Carter ME, Zimmerman GA, McIntyre TM, Prescott SM (1989). Lipoproteins alter the catalytic behavior of the platelet-activating factor acetylhydrolase in human plasma. Proc Natl Acad Sci USA 86, 2393.
Stafforini DM, McIntyre TM, Carter ME, Prescott SM (1987). Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor. J Biol Chem 262, 4215.


Stafforini DM, Prescott SM, McIntyre TM (1987). Human plasma platelet-activating factor acetylhydrolase. Purification and properties. J Biol Chem 262, 4223.