Cindy Lu Ph.D.

EDUCATION

2004 Ph.D, Molecular and Cellular Biology, Harvard University, Cambridge, MA

1995 BA, Molecular and Cellular Biology, University of California, Berkeley, CA, BA, French Language, University of California, Berkeley, CA

WORK EXPERIENCE

2017 – present Consultant/Writer MIT, Department of Architecture, Cambridge, MA

2014 – 2016 Scientific Editor Cell, Cell Press, Cambridge, MA

2004 – 2014 Postdoctoral Researcher Harvard Medical School, Department of Neurobiology Laboratory of Dr. Lisa V. Goodrich Wiring the cochlea to the brain. • Generation of a comprehensive, searchable online gene expression database for spiral and vestibular ganglion neurons, spanning all stages of circuit assembly • Demonstration that the transcription factor Gata3 coordinates the timing and pattern of spiral ganglion neuron peripheral axon growth and maintains auditory identity of these neurons during circuit assembly • Identification of the first spiral ganglion central axon branching gene, Npr2, which is necessary for reliable action potential propagation.

1997 – 2004 Doctoral research Department of Molecular and Cellular Biology, Harvard University Laboratory of Dr. Elizabeth J. Robertson The role of Nodal signaling in anterior-posterior axis formation in the early mouse embryo. • Demonstrated that Nodal signaling establishes global anterior-posterior patterning in the early mouse embryo through complex, reciprocal interactions between embryonic and extraembryonic tissues • Uncovered a novel Nodal-dependent anterior-posterior cell sorting mechanism in the epiblast

1996 – 1997 Research Assistant Department of Ophthalmology, University of California, San Francisco Laboratory of Dr. David W. Sretavan The role of GAP-43 in retinal ganglion cell axonal guidance at the mouse optic chiasm

1993 – 1995 Undergraduate Honors Thesis Research Department of Molecular and Cell Biology, University of California, Berkeley Laboratory of Dr. Kathryn V. Anderson Characterization of mutants affecting dorsal-ventral polarity in fly embryos

AWARDS AND RESIDENCIES

SCIENTIFIC

2008 – 2009 National Organization of Hearing Research Seed Money Grant

2006 – 2008 Ruth L. Kirschstein NRSA F32 Postdoctoral Fellowship

ART

2019 Visiting Artist (summer MFA – BLR program) MassArt, Boston, MA

2018 First prize award, Techne (juried exhibition) Arthaus Projects, Williamsport, PA

2018 First prize award, Small Works Salon (juried exhibition) Chandler Gallery, Maud Morgan Art Center, Cambridge, MA

TEACHING EXPERIENCE

1999 Teaching Fellow, Harvard University Molecular Genetics of Developmental Neurobiology

1999 Teaching Fellow, Harvard University Introductory Biology

1998 High school level Biology Tutor

PRESENTATIONS

SELECTED TALKS

2012 Eaton-Peabody Lab Seminar Series, Mass Eye and Ear Infirmary Wiring the cochlea to the brain

2012 Molecular Biology of the Inner Ear Lecture Series, Harvard Medical School Molecular mechanisms of auditory circuit assembly

2010 The Mouse as an Instrument for Ear Research, Jackson Labs How to wire the cochlea

2010 Auditory System Gordon Research Conference Expression profiling during auditory circuit assembly identifies Npr2 as a regulator of spiral ganglion axon bifurcation

2010 Auditory System Gordon Research Seminar Expression profiling during auditory circuit assembly identifies Npr2 as a regulator of spiral ganglion axon bifurcation

2010 Association for Research in Otolaryngology Conference Expression profiling during auditory circuit assembly identifies Npr2 as a regulator of spiral ganglion axon bifurcation

SELECTED POSTERS

2012 Association for Research in Otolaryngology Conference Innervation of the ventral cochlear nucleus in mice that Npr2, a receptor guanylyl cyclase

2009 Molecular Biology of Hearing and Deafness Conference Axon branching in spiral ganglion neurons

2008 Society for Developmental Biology Conference Axon branching in spiral ganglion neurons

ART EXHIBITIONS

SOLO

2019 Solo exhibition, Suspended Embrace Arthaus Projects, Williamsport, PA

2018 Solo exhibition, Data Collection Chandler Gallery, Maud Morgan Art Center, Cambridge, MA

JURIED GROUP

2019 Fay Chandler Emerging Artists Exhibit Scollay Square Gallery, Boston City Hall, Boston, MA

2019 Unconventional Davis Gallery, Worcester, MA

2019 Please Touch the Art Mosesian Center for the Arts, Watertown, MA

2019 Tin Ceilings and Other Specifics The Magenta Suite, Exeter, NH

2019 Fiberlicious! Loading Dock Gallery, Lowell, MA

2018 Humanities Approaches to the Opioid Crisis Center for the Humanities and School of Public Health, Boston University, Boston, MA

2018 Art Party Friday Arts Project, Rock Hill, SC

2018 Shelter Philadelphia Sculptors & Da Vinci Art Alliance, Philadelphia, PA

2018 Techne Arthaus Projects, Williamsport, PA

2018 Small Works Salon Chandler Gallery, Maud Morgan Art Center, Cambridge, MA

SELECTED PUBLICATIONS

Lu CC, Cao XJ, Wright S, Leung H, Ma L, Oertel D, Goodrich LV. Loss of Npr2 blurs the tonotopic organization of the cochlear nuclei without affecting the temporal precision of functional connections. PLoS Genet. 2014 Dec 4;10(12):e1004823.

Appler JM*, Lu CC*, Druckenbrod NR, Yu WM, Koundakjian EJ, Goodrich LV. Gata3 is a critical regulator of cochlear wiring. J Neurosci. 2013 Feb 20; 33(8):3679-3691.

Lu CC *, Appler JM *, Houseman EA, Goodrich LV. Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci. 2011 Jul 27; 31(30): 10903-18.

Abraira VE *, Hyun N*, Tucker AF*, Coling DE, Brown MC, Lu C, Hoffman G, Goodrich LV. Changes in Sef levels influence auditory brainstem development and function. J. Neurosci. 2007 Apr 18; 27(16): 4273-82.

Ben-Haim N, Lu C, Guzman-Ayala M, Pescatore L, Mesnard D, Bischofberger M, Naef F, Robertson EJ, Constam DB. The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. Dev Cell. 2006 Sep; 11(3):313-23.

Lu CC and Robertson EJ. Multiple Roles for Nodal Signaling in Anterior-Posterior Patterning. Developmental Biology. 2004 Sep 1; 273(1):149-59

Lu CC, Robertson EJ, Brennan J. The Mouse Frizzled 8 Receptor is Expressed in Anterior Organizer Tissues. Gene Expr Patterns. 2004 Sep; 4(5):569-72. Lu CC, Brennan J, Robertson EJ. From fertilization to gastrulation: axis formation in the mouse embryo. Curr Opin Genet Dev. 2001 Aug; 11(4):384-92. Review.

Brennan J, Lu CC, Norris DP, Rodriguez TA, Beddington RS, Robertson EJ. Nodal signalling in the epiblast patterns the early mouse embryo. Nature. 2001 Jun 21;411(6840):965-9.

Zhang F*, Lu C*, Severin C, Sretavan DW. GAP-43 mediates retinal axon interaction with lateral diencephalon cells during optic tract formation. Development. 2000 Mar; 127(5): 969-80.

Kruger K, Tam AS, Lu C, Sretavan DW. Retinal ganglion cell axon progression from the optic chiasm to initiate optic tract development requires cell autonomous function of GAP-43. J Neurosci. 1998 Aug 1; 18(15): 5692- 705.

* These authors contributed equally to this work