Altered RNA-processing provides a mechanistic framework delineating human sex-reversal associated with pathogenic variants in the RNA-helicase DHX37

Last month, the UK Supreme Court ruled that the legal definition of a woman is based on biological sex. Snippets are not the place for discussing legal rulings and their ramifications, but I want to focus on one quote from the decision: “the concept of sex is binary, a person is either a woman or a man”. Such simplicity might be convenient in terms of legal clarity but is at odds with the reality of human biology. Biological sex is…

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